TB-500 (Thymosin Beta 4) (5mg / 10mg)

Description

TB-500 Peptide – Overview

TB-500, also known as synthetic Thymosin Beta 4 (Tβ4), is a synthetic version of the naturally occurring protein Thymosin Beta 4. This protein is found in thymus cells and encoded by the TMSB4X gene. TB-500 is a 43-amino-acid peptide that is highly soluble in water and lightweight.

Researchers suggest TB-500 may support wound healing, angiogenesis, and tissue regeneration. Additionally, the peptide may influence hair growth and aid in neurological repair, as well as recovery of the spinal cord, heart, and epidermal tissues.

Mechanism of Action

The active site of TB-500 is the peptide segment LKKTETQ, which may impact actin binding, cell migration, and tissue repair. Actins are proteins essential for maintaining cellular structure and enabling movement.

TB-500 interacts with globular actin (G-actin) to prevent its transformation into filamentous actin (F-actin). This process increases the availability of G-actin, which can enhance cell motility and facilitate wound healing and tissue regeneration. TB-500 also exhibits potential extracellular activity, supporting angiogenesis and cellular functions through interactions with ATP synthase enzymes.

Chemical Profile

• Molecular Formula: C212H350N56O78S

• Molecular Weight: 4963 g/mol

• Other Name: Thymosin Beta 4

TB-500 and Inflammation

TB-500 may increase levels of microRNA-146a (miR-146a), a regulator of inflammation-related pathways. This microRNA may influence IRAK1 and TRAF6, which are critical in cytokine signaling. Studies suggest that TB-500’s regulation of these factors could contribute to its anti-inflammatory potential.

TB-500 and Wound Healing

Acute Wounds

In 1999, TB-500 was tested in murine wound models. After four days, treated wounds exhibited a 41% increase in re-epithelialization compared to controls. By seven days, wounds contracted 11% more than saline-treated wounds. These results indicate TB-500 may promote angiogenesis and collagen deposition, accelerating wound healing.

Chronic Wounds

TB-500 has shown potential in various chronic wound models, including diabetic and aged mice. The peptide accelerated wound healing across all models, suggesting broad applicability. Phase 2 clinical trials for stasis and pressure ulcers reported healing improvement of up to one month.

TB-500 and Cardiac Health

TB-500 may support heart cell regeneration. Studies in pulmonary hypertension models suggest TB-500 reduces right ventricular hypertrophy and enhances cardiac cell resilience under hypoxic conditions.

Research indicates TB-500 may promote angiogenesis, improve integrin-linked kinase (ILK) and Akt signaling, and stimulate myocardial and endothelial cell migration. These actions suggest TB-500 may aid cardiac tissue repair and enhance overall heart function. You may also be interested in our related research peptides, including bpc 157, bpc 157 peptide, Tesamorelin, ghk cu peptide, tesamorelin peptide, cjc 1295 ipamorelin, mots-c, semax, and PT-141. For research use only.

Summary

TB-500 is a versatile peptide with potential applications in wound healing, anti-inflammation, and cardiac regeneration. Research demonstrates its ability to promote angiogenesis, enhance tissue repair, and support cellular motility. Its multi-faceted role makes TB-500 a promising peptide for regenerative medicine and tissue recovery.