DSIP (5mg)

Description

DSIP (Delta Sleep-Inducing Peptide) – Sleep, Stress, and Longevity Support

Delta Sleep-Inducing Peptide (DSIP) is a naturally occurring nonapeptide composed of nine amino acids. Scientists first isolated it from the central nervous system in experimental models of electrically induced sleep. DSIP is suggested to regulate sleep cycles, improve slow-wave sleep, and influence physiological processes, including stress response and neurotransmitter modulation. Early studies indicated DSIP may also reduce pain and alleviate withdrawal symptoms.

Chemical Makeup

• Molecular Formula: C35H48N10O15

• Molecular Weight: 848.82 g/mol

• Other Names: DSIP nonapeptide, Emideltide

Mechanisms of Action

DSIP may improve sleep by interacting with the central nervous system. It could reduce sleep onset time and enhance sleep quality by modulating neurotransmitter activity. The peptide appears to target several key receptors:

• NMDA and GABA receptors: DSIP may dampen NMDA-mediated excitatory signals while amplifying GABA’s inhibitory effects, helping calm the brain and promote sleep.

• Opioid receptors: DSIP may indirectly influence opioid receptors, supporting both sleep regulation and withdrawal mitigation.

• Alpha 1-adrenergic receptors: Located in the pineal gland, these receptors may mediate DSIP’s effects on sleep and stress tolerance.

DSIP and Sleep Cycles

Animal studies suggest DSIP enhances slow-wave sleep (SWS). In feline models, total sleep and SWS increased significantly within the first hour of DSIP administration and maintained higher levels for seven hours. SWS, a deep sleep stage within non-REM (NREM) sleep, is associated with delta waves and restorative brain function.

Clinical observations indicate DSIP may increase sleep pressure and improve sleep efficiency, potentially shortening the time needed to fall asleep.

DSIP and Endocrine Regulation

DSIP may influence hormonal secretions during sleep. In murine studies, it elevated luteinizing hormone (LH) within 30 minutes, with minimal effect on follicle-stimulating hormone (FSH). The peptide also increased growth hormone (GH) release, likely via hypothalamic regulation and dopaminergic pathways. In vitro studies with pituitary cells confirmed this GH increase, although higher DSIP concentrations reduced the effect, suggesting a dose-dependent response.

DSIP and Stress Response

Researchers tested DSIP in mice exposed to experimental stress. DSIP appeared to modulate stress markers such as substance P, beta-endorphin, and corticosterone. For example, beta-endorphin initially decreased and later surged, suggesting DSIP influences the opioidergic system. Corticosterone levels dropped shortly after administration, indicating potential stress-reducing properties. You may also be interested in our related research peptides, including bpc 157, bpc 157 peptide, Tesamorelin, ghk cu peptide, tesamorelin peptide, cjc 1295 ipamorelin, mots-c, semax, and PT-141. For research use only.

DSIP and Longevity

DSIP may support longevity and reduce oxidative stress. Studies indicate that DSIP:

• Decreased chromosomal aberrations in bone marrow by 23%

• Improved lifespan by 24%

• Reduced malignancy incidence 2.5-fold

Its potential antioxidative effects include inhibiting malonic dialdehyde, a byproduct of lipid peroxidation, and stimulating endogenous antioxidants like superoxide dismutase (SOD), catalase, and ceruloplasmin. These effects suggest DSIP may help maintain cellular defenses during aging.

Conclusion

DSIP shows promise in supporting sleep quality, endocrine function, stress response, and longevity. By modulating neurotransmitters, hormonal secretion, and antioxidant defenses, it may provide multifaceted benefits for research purposes.

DSIP peptide is intended for research and laboratory use only. Review our Terms and Conditions before ordering.

References:

1. National Center for Biotechnology Information. “PubChem Compound Summary for CID 3623358, Emideltide;delta Sleep Inducing Peptide” PubChem, https://pubchem.ncbi.nlm.nih.gov/compound/3623358
2. Graf MV, Kastin AJ. Delta-sleep-inducing peptide (DSIP): an update. Peptides. 1986 Nov-Dec;7(6):1165-87. https://pubmed.ncbi.nlm.nih.gov/3550726/
3. Kovalzon VM, Strekalova TV. Delta sleep-inducing peptide (DSIP): a still unresolved riddle. J Neurochem. 2006 Apr;97(2):303-9. https://pubmed.ncbi.nlm.nih.gov/16539679/
4. Grigor’ev VV, Ivanova TA, Kustova EA, Petrova LN, Serkova TP, Bachurin SO. Effects of delta sleep-inducing peptide on pre- and postsynaptic glutamate and postsynaptic GABA receptors in neurons of the cortex, hippocampus, and cerebellum in rats. Bull Exp Biol Med. 2006 Aug;142(2):186-8. English, Russian. doi: 10.1007/s10517-006-0323-9. PMID: 17369935
5. Sudakov KV, Umriukhin PE, Rayevsky KS. Delta-sleep inducing peptide and neuronal activity after glutamate microiontophoresis: the role of NMDA-receptors. Pathophysiology. 2004 Oct;11(2):81-86. https://pubmed.ncbi.nlm.nih.gov/15364118/
6. Nakamura A, Nakashima M, Sakai K, Niwa M, Nozaki M, Shiomi H. Delta-sleep-inducing peptide (DSIP) stimulates the release of immunoreactive Met-enkephalin from rat lower brainstem slices in vitro. Brain Res. 1989 Feb 27;481(1):165-8. doi: 10.1016/0006-8993(89)90498-8. PMID: 2706459.
7. Dick P, Grandjean ME, Tissot R. Successful treatment of withdrawal symptoms with delta sleep-inducing peptide, a neuropeptide with potential agonistic activity on opiate receptors. Neuropsychobiology. 1983;10(4):205-8. doi: 10.1159/000118012. PMID: 6328354.
8. Graf MV, Schoenenberger GA. Delta sleep-inducing peptide modulates the stimulation of rat pineal N-acetyltransferase activity by involving the alpha 1-adrenergic receptor. J Neurochem. 1987 Apr;48(4):1252-7. doi: 10.1111/j.1471-4159.1987.tb05654.x. PMID: 3029331.
9. Susić V, Masirević G, Totić S. The effects of delta-sleep-inducing peptide (DSIP) on wakefulness and sleep patterns in the cat. Brain Res. 1987 Jun 30;414(2):262-70. https://pubmed.ncbi.nlm.nih.gov/3620931/
10. Schneider-Helmert D, Gnirss F, Monnier M, Schenker J, Schoenenberger GA. Acute and delayed effects of DSIP (delta sleep-inducing peptide) on human sleep behavior. Int J Clin Pharmacol Ther Toxicol. 1981 Aug;19(8):341-5. https://pubmed.ncbi.nlm.nih.gov/6895513/
11. Iyer KS, McCann SM. Delta sleep inducing peptide (DSIP) stimulates the release of LH but not FSH via a hypothalamic site of action in the rat. Brain Res Bull. 1987 Nov;19(5):535-8. doi: 10.1016/0361-9230(87)90069-4. https://pubmed.ncbi.nlm.nih.gov/3121137/
12. Iyer KS, McCann SM. Delta sleep-inducing peptide (DSIP) stimulates growth hormone (GH) release in the rat by hypothalamic and pituitary actions. Peptides. 1987 Jan-Feb;8(1):45-8. doi: 10.1016/0196-9781(87)90163-x. PMID: 3575154.
13. Sudakov KV, Coghlan JP, Kotov AV, Salieva RM, Polyntsev YuV, Koplik EV. Delta-sleep-inducing peptide sequels in the mechanisms of resistance to emotional stress. Ann N Y Acad Sci. 1995 Dec 29;771:240-51. https://pubmed.ncbi.nlm.nih.gov/8597403/
14. Popovich IG, Voitenkov BO, Anisimov VN, Ivanov VT, Mikhaleva II, Zabezhinski MA, Alimova IN, Baturin DA, Zavarzina NY, Rosenfeld SV, Semenchenko AV, Yashin AI. Effect of delta-sleep inducing peptide-containing preparation Deltaran on biomarkers of aging, life span and spontaneous tumor incidence in female SHR mice. Mech Ageing Dev. 2003 Jun;124(6). https://pubmed.ncbi.nlm.nih.gov/12782416/
15. Bondarenko TI, Maĭboroda EA, Mikhaleva II, Prudchenko IA. [Mechanism of delta-sleep inducing peptide geroprotective activity]. Adv Gerontol. 2011;24(1):80-92. Russian. https://pubmed.ncbi.nlm.nih.gov/21809625/