Description

Tripeptide-29

Tripeptide-29 is a small, naturally occurring amino acid peptide and a key building block of collagen protein. Collagen forms a major component of the extracellular matrix, providing structure and support to connective tissues. Researchers suggest that Tripeptide-29 may stimulate collagen synthesis, promote the formation of collagen fibers, and contribute to overall skin and tissue integrity.

In addition to its role in collagen production, Tripeptide-29 may exhibit antioxidant, anti-inflammatory, anti-fibrotic, and anti-melanogenic properties, helping protect cells from oxidative stress and damage.

Chemical Composition

• Molecular Formula: C12H19N3O5

• Molecular Weight: 285.3 g/mol

• Other Names: Glycylprolylhydroxyproline

Collagen Integrity and Skin Health

Tripeptide-29 plays a critical role in stabilizing type I collagen molecules. Studies suggest that the hydroxy group of proline (Hyp) in Tripeptide-29 contributes to favorable interatomic interactions that enhance collagen and microfibril stability. Its presence may reduce UV-induced collagen damage and slow degradation under intense radiation.

Research on dermal fibroblasts showed that hydrolyzed collagen tripeptides, primarily Tripeptide-29, can reduce oxidative stress and prevent the formation of advanced glycation end products (AGEs). By limiting glycation and oxidative damage, Tripeptide-29 may preserve collagen integrity, improve cell aging phenotypes, and support skin elasticity. Its small size likely facilitates deeper skin penetration and bioavailability, enhancing its protective effects.

Tripeptide-29 may also inhibit matrix metalloproteinases (MMPs) while increasing collagen I levels, further preserving the structural integrity of the extracellular matrix. You may also be interested in our related research peptides, including GHRP 2 Peptide, Fragment 176-191, Follistatin 344, LL-37 Peptide, Melanotan 2 Peptide, CJC-1295 DAC Peptide, Adipotide Peptide, MGF peptide, PEG-MGF Peptide, and Vilon Peptide.

Glucose Regulation Potential

itmay act as a peptidic inhibitor of dipeptidyl peptidase-IV (DPP-IV) by preventing the hydrolysis of the Pro-Hyp bond. This property allows Tripeptide-29 to remain stable in the presence of DPP-IV, potentially enhancing its biological activity.

DPP-IV regulates hormones involved in glucose homeostasis, such as GLP-1, GIP, and peptide YY (PYY). By inhibiting DPP-IV, Tripeptide-29 may increase GLP-1 and GIP levels, which could enhance insulin secretion, reduce glucagon, lower blood glucose, and regulate appetite.

Platelet Aggregation and Blood Clotting

Collagen-related peptides containing glycine-proline-hydroxyproline repeats may stimulate platelet aggregation via glycoprotein VI (GPVI) receptors, which are essential for blood clotting. GPVI consists of alpha and beta subunits; the alpha subunit binds collagen while the beta subunit signals platelet activation.

Tripeptide-29, even in its non-cross-linked form, can induce tyrosine phosphorylation of Syk kinase and PLCγ2, promoting platelet aggregation. This suggests that this may help prevent excessive bleeding by supporting thrombus formation.

Research and Usage

This product is primarily available for research and laboratory purposes. Users should adhere to all applicable safety guidelines and review the Terms and Conditions before ordering.