AOD 9604 (5mg)

AOD 9604 Peptide – Overview

AOD 9604 is a synthetic analog of growth hormone (GH) designed to support weight management. This peptide reproduces the last 16 amino acids (176–191) of GH, often referred to as GH Fragment 176–191. Researchers modified the N-terminal amino acid with tyrosine to improve the peptide’s stability.

AOD 9604 is known as the lipolytic fragment of GH because it targets fat metabolism while avoiding stimulation of insulin-like growth factor 1 (IGF-1), unlike natural GH.

Mechanism of Action

AOD 9604 enhances lipolysis, the breakdown of fat stored in adipose tissue into glycerol and free fatty acids. Enzymes like lipase help convert these fats into energy used by cells. Research suggests that AOD 9604 may increase the sensitivity of beta-3 adrenergic receptors (β3-AR), key lipolytic receptors in fat cells.

Interestingly, while AOD 9604 upregulates β3-AR, it may not act directly through this receptor to induce fat loss. Instead, its effects may involve increasing energy expenditure and fat oxidation, helping the body burn stored fat efficiently.

Research and Clinical Studies on Weight Loss

Early animal studies demonstrated that AOD 9604 reduced fat and weight in obese mice. In these studies, the peptide increased lipolytic receptor levels and fat metabolism. Research in obese Zucker rats also confirmed similar findings, showing significant weight reduction after daily dosing for 19 days.

In humans, a clinical trial involving 300 obese participants over 12 weeks showed consistent weight loss. The study reported modest improvements in cholesterol and glucose tolerance. These results indicate that AOD 9604 may safely support weight management without altering insulin sensitivity.

AOD 9604 and Tissue Regeneration

Beyond fat metabolism, AOD 9604 may support tissue repair. A 2015 study in rabbits found that combining AOD 9604 with hyaluronic acid reduced cartilage degeneration. The peptide appears to enhance the differentiation of mesenchymal stem cells, potentially promoting bone, muscle, and cartilage repair.

Laboratory studies also show that AOD 9604 may stimulate chondrocytes to produce collagen and proteoglycans. Additionally, it may encourage myoblasts to mature into muscle cells, suggesting potential benefits in musculoskeletal regeneration.

Potential Role in Cancer Research

Emerging research suggests this may enhance the delivery of anticancer drugs. In one study, combining this with doxorubicin-loaded chitosan nanoparticles improved drug targeting to breast cancer cells (MCF-7). This combination increased anticancer efficacy while potentially reducing non-target tissue exposure.

Chemical Profile of AOD 9604

• Molecular Formula: C78H123N23O23S2

• Molecular Weight: 1815.12 g/mol

• Other Name: Tyr-hGH Fragment 177–191

Summary

AOD 9604 is a synthetic GH fragment that supports fat metabolism, weight management, and tissue regeneration. Clinical and preclinical studies suggest it promotes lipolysis, increases energy expenditure, and may enhance stem cell differentiation for tissue repair. Additionally, it shows potential to improve targeted drug delivery in cancer research.

This peptide offers a promising approach for safe weight management and metabolic support without the unwanted effects of natural growth hormone. You may also be interested in our related research peptides, including bpc 157, bpc 157 peptide, Tesamorelin, ghk cu peptide, tesamorelin peptide, cjc 1295 ipamorelin, mots-c, semax, and PT-141. For research use only.