Semax (25mg)

Description

Semax Peptide

Semax is a synthetic polypeptide derived from the adrenocorticotropic hormone fragment ACTH (4–7). Scientists designed it to retain brain-related activity while removing the hormonal effects linked to ACTH.

Unlike natural peptides, which break down quickly, this compound offers improved stability. Researchers enhanced its structure by adding a Pro-Gly-Pro (PGP) sequence. This adjustment may improve its ability to cross the blood-brain barrier and resist enzymatic degradation.

As a result, it remains a strong candidate for studies involving brain signaling and neurological processes.

Overview and Mechanism of Action

Researchers suggest this compound may influence several brain functions. First, it appears to slow the breakdown of enkephalins neurotransmitters linked to pain and stress.

In addition, it may affect dopamine and serotonin levels. These interactions could influence mood, cognition, and neural communication. Because these systems are interconnected, even minor changes may lead to broader effects.

Furthermore, studies indicate a possible increase in brain-derived neurotrophic factor (BDNF). This protein supports neuron growth and survival.

It may also regulate gene expression tied to immune responses, potentially influencing immune cell activity.

Chemical Makeup

• Molecular Formula: C39H54N10O10S

• Molecular Weight: 854.99 g/mol

• Other Names: ACTH (4-7) PGP, HY-P1146

Research and Studies

Cognitive Function and Nootropic Potential

Research suggests this compound may support cognitive performance. In one study, scientists observed increased levels of 5-HIAA, a serotonin metabolite.

These levels rose within hours, indicating enhanced serotonergic activity. As a result, the compound may influence mood, memory, and focus.

Moreover, when combined with stimulants, it appeared to amplify these effects, suggesting interaction with multiple neurotransmitter systems.

Effects on Stress and Anxiety Models

Studies on neonatal models highlight its possible role in stress regulation. Initially, subjects exposed to SSRIs showed increased anxiety and reduced adaptability.

However, after exposure, researchers noted improved learning ability and reduced anxiety-like behavior. These effects appeared stable over time.

Additionally, the compound may help rebalance monoamines such as serotonin, dopamine, and norepinephrine, supporting emotional stability.

Role in Vascular Function

Researchers have also examined its impact on vascular systems. In myocardial infarction models, it appeared to reduce cardiac stress and support structural function.

Specifically, it helped control pressure buildup and supported healthier cardiac remodeling.

Neuroprotective Properties

This compound has demonstrated potential neuroprotective effects in experimental settings. In stroke-related studies, researchers observed faster recovery of neurological function.

EEG data supported these findings, showing improved brain activity patterns.

Impact on Memory and Focus

Under high-stress conditions, subjects showed improved memory recall and focus within 24 hours. These findings suggest potential benefits for cognitive performance in demanding situations.

Semax peptide is available for research and laboratory purposes only. Please review and adhere to our Terms and Conditions before ordering.

References:

1. T. Kolomin et al., A New Generation of Drugs: Synthetic Peptides based on Natural Regulatory peptides. Neuroscience & Medicine, 2013, 223-252. Published Online December 2013. https://dx.doi.org/10.4236/nm.2013.44035
2. Dornbush RL, Nikolovski O. ACTH 4-10 and short-term memory. Pharmacol Biochem Behav. 1976;5(Suppl 1):69-72. doi: 10.1016/0091-3057(76)90331-2. PMID: 189333. https://pubmed.ncbi.nlm.nih.gov/189333/
3. Kost NV, Sokolov OIu, Gabaeva MV, Grivennikov IA, Andreeva LA, Miasoedov NF, Zozulia AA. Ingibiruiushchee deĭstvie semaksa i selanka na énkefalindegradiruiushchie fermenty syvorotki krovi cheloveka [Semax and selank inhibit the enkephalin-degrading enzymes from human serum]]. Bioorg Khim. 2001 May-Jun;27(3):180-3. Russian. doi: 10.1023/a:1011373002885. PMID: 11443939. https://pubmed.ncbi.nlm.nih.gov/11443939/
4. Shih-Jen Tsai, Semax, an analogue of adrenocorticotropin (4–10), is a potential agent for the treatment of attention-deficit hyperactivity disorder and Rett syndrome, Medical Hypotheses, Volume 68, Issue 5, 2007, Pages 1144-1146. https://doi.org/10.1016/j.mehy.2006.07.017
5. Medvedeva, E.V., Dmitrieva, V.G., Povarova, O.V. et al. The peptide semax affects the expression of genes related to the immune and vascular systems in rat brain focal ischemia: genome-wide transcriptional analysis. BMC Genomics 15, 228 (2014). https://doi.org/10.1186/1471-2164-15-228
6. Eremin KO, Kudrin VS, Saransaari P, Oja SS, Grivennikov IA, Myasoedov NF, Rayevsky KS. Semax, an ACTH(4-10) analogue with nootropic properties, activates dopaminergic and serotoninergic brain systems in rodents. Neurochem Res. 2005 Dec;30(12):1493-500. doi: 10.1007/s11064-005-8826-8. PMID: 16362768.
7. Nataliya Yu. Glazova, Daria M. Manchenko, Maria A. Volodina, Svetlana A. Merchieva, Ludmila A. Andreeva, Vladimir S. Kudrin, Nikolai F. Myasoedov, Natalia G. Levitskaya, Semax, synthetic ACTH(4–10) analogue, attenuates behavioural and neurochemical alterations following early-life fluvoxamine exposure in white rats, Neuropeptides, Volume 86, 2021, 102114, ISSN 0143-4179. https://doi.org/10.1016/j.npep.2020.102114
8. Gavrilova SA, Golubeva AV, Lipina TV, Fominykh ES, Shornikova MV, Postnikov AB, Andrejeva LA, Chentsov IuS, Koshelev VB. [Protective effect of peptide semax (ACTH(4-7)Pro-Gly-Pro) on the rat heart rate after myocardial infarction]. Ross Fiziol Zh Im I M Sechenova. 2006 Nov;92(11):1305-21. Russian. PMID: 17385423. https://pubmed.ncbi.nlm.nih.gov/17385423/